New research indicates that people who come off new slimming jabs like semaglutide or tirzepatide can put back on lost weight much more quickly than those who end conventional lifestyle programs.
Findings released in a prominent medical journal shows that while overweight people often shed a large proportion of their total mass while undergoing treatment, the mass comes back at an estimated rate of 0.8 kg per month upon discontinuation.
"Users purchasing such treatments must be cognizant of the danger of rapid rebound weight gain when the therapy concludes," stated researcher Dr. Susan Jebb.
Such speed of regain implies a reversion to pre-treatment mass in about a year and a half.
Comparing Approaches
The analysis, which reviewed 37 of trials involving thousands of participants, contrasted the effects of the injectable medications with older methods.
The team emphasize that people who shed pounds through dieting generally see a more gradual weight regain—perhaps 100 grams monthly—after stopping.
Explaining the Rapid Rebound
Nutrition scientists believe the mechanism of the injections explains the heightened weight return.
GLP-1 drugs copy a natural hormone called glucagon-like peptide-1, which helps regulate hunger.
"Long-term administration of GLP-1 concentrations far above than the body's typical production may cause the body to generate a reduced amount of its own natural hormone, and could diminish responsiveness to its effects," explained Dr. Adam Collins, a nutrition expert.
"Discontinuation of this medication leads to hunger is uncontrolled, making overeating far more likely."
An Ongoing Condition?
Health authorities recommend the injections for people with weight-linked health risks, accompanied by recommended lifestyle changes.
Professionals say that, considering the likelihood of relapse, the therapy is often ongoing.
This view is echoed by drug manufacturers, who note that the results "underscore the chronic character of excess weight," akin to managing conditions like high blood pressure.
User Testimonies
Individuals who have come off the jabs report a sudden return of hunger.
"I experienced a switch flipping and you become ravenous," said one woman.
This challenge is exacerbated if users have not adopted permanent lifestyle or habit modifications during therapy.
Widespread Interest
Survey data show that a significant number of adults in the UK have used these injections in the past year, with demand being substantial.
- Use is higher among females than males.
- The 40s and 50s age group shows the highest usage rates.
- A large proportion obtain the medications through private healthcare rather than the NHS.
Finally, experts stress that while the jabs are effective agents for shedding pounds, they are not a standalone cure and lasting health benefits hinges on integrated lifestyle changes.
